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Could be the Blu-ray lens is faulty or your any-virus is blocking some files, either the Blu-ray itself and/or the software in both Media Smart DVD and DVD10. Maybe something simple like a dirty lens, start there first.
Uninstall your anti virus software, what ever that may be and also any third party firewall program you may be running (eg Comodo Firewall). Be sure to go to their respective web sites and use any of their tools that are needed to completely get rid of all traces.
Restart ( you may want to go to Windows Access Centre at this point and shut off any annoying warnings that you're running your computer with out any anti-virus program).
Run CCleaner registry cleaner as you did before until it finds nothing and restart.
Uninstall Media Smart DVD and DVD10, run CCleaner same as before and restart.
Make sure that you have not disabled Windows Media player and Windows Media Centre.
Insert your Blu-ray and even though you have no software to play it, the title of the Blu-ray movie will show up in "Computer" under the DVD/BD ROM drive. If it doesn't then I would say the lens is no longer reading the movie.
Use a movie that you know that played before.
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If it sees the movie then install this trial of Total Media Theatre 5. Windows Firewall will block some files and you will get a message(s) for this _ allow them through. TMT 5 will ask you to restart your machine and upon opening the software Windows Firewall may still ask your permission, allow the files in.
Please tell me if your movie plays. This is a new version of TMT5, it should play everything.
http://www.arcsoft.com/totalmedia-theatre/
In the link I provided, click on the free trial button and go no where else as you are running with out an ant-virus program.
Save the file to the desk top and install from there, not from a temporary folder. This is important to save the file to the desk top first.
One of the advantages of TMT 5 is that it's written from scratch, it does not rely on Microsoft Visual Packages for it to run. Microsoft Visual Packages are pr-written software that vendors use to save time when they write their programs. The problem here is that, other things affect them, like antivirus software.
Let me know how things go and we will continue. 
Before you condemn TMT 5 here is a coupon code for 50% off. SOFTTMT5
At check out, just copy and paste the code in the promotion box, or what ever they call it.
I became so fed-up with Cyberlink and their products (for other reasons) that I just went out and bought TMT 5.
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Yes, delete all the MS DVD files in your download folder too, they don't need to be there, I am not sure if that will make a real difference though.
Also Power DVD 10 and maybe MS DVD creates a storage folder in "Documents" right click and delete anything you find there to do with MS DVD amd Power DVD10. There will also be one there for ArcSoft as well, leave that there for now.
Here is the most recent version of DVD10.
ftp://ftp.hp.com/pub/softpaq/sp56501-57000/sp56904
When you click on the link pop-up will appear at the bottom of the screen (Internet Explorer 9). It will have 3 choices, RUN SAVE and CANCEL
Beside SAVE there is a drop down box arrow. Click on the arrow and select SAVE AS. A new window will appear where you want to save it, in the left column look for DESK TOP at the top of that list. Click on that and select SAVE at the bottom right of that screen.
You may get another pop-up saying that this file already exists, click on the REPLACE ALL button to resave it.
Give it some time to download and install DVD10 from the desk top.
After it installs RESTART. It will then become the default Blu-ray player over ArcSoft.
For the first time playing _ Eject the DVD/Blu-ray drawer with the button on the drawer face itself. Load you movie and allow it to play automatically WITH OUT OPENING POWER DVD 10 _ give it some time.
Hopefully it will work this time around.
What is the movie you're trying to play and did you uninstall your anti-virus software or firewall ? I am curious.
Go into programs and features and take a screen shot of your Microsoft Visual C++ packages there.
I want you to delete the one associated with Power 10, but I want to make sure you delete the right one.
They will be in a group like this.
If you're not going to answer my question whether or not you uninstalled your Virus program or not, then I won't continue.
At least tell me what the program it is and what firewall you're running.
And I have Norton Internet security, I uninstalled it to install the TMT5 and have it installed back. im not sure about my firewallUninstall your Norton again and the one with the red box around it. (see screen shot). Also DVD10. (in that order)
Go through the drill again with CCleaner's registry cleaner.
The one in "Green" has a date of January 24, 2012, can you remember what you installed on that date ?
Reinstall Power DVD10 from the link I gave you earlier and follow the instructions as before only this time go into "Auto Play" in the control panel and make sure that Power DVD10 is chosen for Blu-ray playback. If it isn't, choose and save the setting > restart and check and make sure the setting was saved.
Try your movie again as before with out opening DVD10.
It's important to uninstall your Norton before installing DVD10.
If DVD10 works and you reinstall Norton and DVD10 stops working, we'll have to go into it's virus chest and find out what file(s) are being blocked.
