My wife's computer will not boot up.

[DRJMAINE]

Today went to start my wife's computer and got a black screen with statement that the system loader was blocked. cannot get mouse or keyboard to function to choose what to do next.  Powered off, changed the mouse to an older USB Mouse, still no luck.

[Lil_Boy_Blue]

Hi

First:- Turn off the computer, press and hold the PWR button for 4 seconds.

Then - Leave only keyboard and mouse connected, disconnect all externally connected
devices such as Docking Station, USB storage devices, displays, and printers.
Unplug the AC adapter from the computer.

Next - Press and Hold the Power button for 15 seconds to Hard Reset.
Rinse and Repeat

AND/OR - Power on your PC, press Esc (repeatedly), then F2 at the prompt.
Choose System Tests (Fast Test does a 4 minute hardware check).

AND/OR - Windows Logo key + Ctrl + Shift + B
(This key sequence actually restarts you graphics driver (W10 only).)

AND/OR - If you’re using multiple displays, try projecting video to a different monitor.
Press the Windows Logo key + P, select a display, and then press Enter.