Software used to submit the job and the print settings - including Media type, paper size, source, orientation
Document format - for example PDF, Word?
Original label document orientation - for example, document created Portrait with one label on top and the other label below the top label.
Possible source of the issue regardless of the other bits:
Original document orientation is important - trying to change the label orientation "after the fact" can sometimes to done but doing it this way might complicate things quite a bit (sometimes to the point where it is not worth the effort).
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