with the help of WyreNut I have installed the drivers for my Palm TX on my Windows 10 laptop. Following some other posts I was able to install the Palm Desktop 4.2 on the laptop and synchronize the Handheld, but only once.
After the first successful synchronization during the installation of Palm Desktop I can not do the synchronization anymore, the handheld is issuing the message that it has no connection. I did the compatibility check and set it to Windows XP, as on my old computer. Still no synchronization.