Using "regedit" I was able to change the font size larger for use with the Palm Desktop software.
Run "regedit" and export (save) a backup copy for safety File > Export
Search for "FontSmall" Edit > Find > Find what > FontSmall
Click on FontSizeGeneral and change the "Value data" to 16
Run Palm Desktop software and enjoy the new legible font size!
Notes: 1) The location of the Palm Desktop software on my system using "regedit" is: HKEY_CURRENT_USER\Software\U.S. Robotics\Pilot Desktop\Core * Your location of the Palm Desktop software may differ.
2) I tested this on monitors using resolutions of 1280 x 1024 and 1024 x 768 The font size is noticeably readable and much, much better
3) You may also change the font family from the default (Arial) to another, such as Verdana, etc. FontCard (Changes the font family in the side panels) FontGeneral (Changes the font family for most of the program fonts)
4) Operating System: Windows XP Pro Palm Desktop v4.1.4