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Mixing of RAM Memory Sizes

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HP Z4 G4 Workstation
Microsoft Windows 10 (64-bit)

Currently have  2 - HP 16GB DDR4 2933 MHz Registered ECC Memory modules and looking to add 2 - HP 32GB DDR4 2933 MHz Registered ECC Memory modules that would bring up to 96GB.  Can the mixing of sizes be done without affecting system performance?  Appreciate any advise.

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Everything depends
The modules are compatible with each other, no problem, the modules will work at the same and correct frequency
The modules are not compatible with each other, either it does not work at all, or the frequency can be reduced
The loss could be very small

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If the modules are same model, you won´t have any problem. Sizes are not usually the problem, but so are the speeds

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