After months of enduring problems with Microsoft Edge (my default - msn.com non responsive) not waking up after sleep, and needing a System Restart to overcome the problem, I seemed to have found my answer by pure chance; Google Chrome and the rest of the PC functioning correctly, but exasperatingly slowly. Over the months I performed the System File Checker (SFC) scan with nothing ever shown as a problem. I'd changed from Norton to Kaspersky Total Security software and thought that was the problem as the PC started playing up just after I installed that, but that also coincided with a Windows10 upgrade and a Power Adapter failure.
I checked many forums for answers to the problem, followed their suggestions with no success.
I also run IBM Trusteer Rapport software which is compatible with my Security software. I decided to reinstall that software last week as I rarely ever use a site which required it, so hadn't checked for updates on it; as soon as the IBM Trusteer Rapport reinstall completed, Microsoft Edge (msn.com) started without a problem, and has worked correctly ever since: waking up from sleep without any issues. My computer speed has dramatically increased, it is like a new computer again. My e mail program which was forever slowing up to save drafts, seems to have gained a new lease of life. I am hopeful that this improvement will continue, so although it may not solve everyone's problems, reinstalling IBM Trusteer Rapport certainly seems to have solved mine.