The z820 is SLI-capable, but in those days, only the top two Quadro GPU's were SLI-certified.
Before running SLI, consult the makers of the software you're using. Adobe CS /CC for years has not been able to address multiple GPU's, even when they are on a single card such as GTX 680.
If the goal is to increase compute power and you already have a K4000, consider adding a Tesla C2075 GPU coprocessor. The C2075 adds 6GB and 448 CUDA cores.
However, if you'd like to significantly improve the GPU performance, have a look at Quadro P1000 4GB ($330) and P2000 5GB ($450). Last Friday, I tried a Quadro P2000 in a z420 (E5-1660 v2) and the Passmark 3D score- which had been 5022 using a Quadro K4200, changed to 8950- faster than a GTX 1060- and faster than the average Quadro K6000, Titan Black , and Quadro M5000. The P1000 is a very good value also, having a Passmark 3D average of 4594. Compare the P1000 figure to the Quadro K4200 at 4456 and K4000 at 2845. But, in my view, the P2000 is well worth stretching the budget a bit. The really astounding one is the $850, Quadro P4000 8GB = 10903 where P5000 = 10821, and the M6000 24GB- $5,000 = 10301. The p4000 I believe could be a good investment, it's considered VR-and 5K capable and so should be useful in the z820 and the system that follows - 4 or 5 years.
Assembled last Friday: new case / chassis, CPU, GPU / Used: motherboard, RAM, drives:
HP z620_2 > Xeon E5-1680 v2 (8-core@ 4.1GHz) / 64GB DDR3-1866 ECC Reg / Quadro P2000/ HP Z Turbo Drive M.2 256GB + Intel 730 480GB + Seagate Constellation ES.3 1TB / ASUS Essence STX PCIe sound card /825W PSU / Windows 7 Prof. 64-bit > HP 2711x monitor [Passmark Rating = 6166 / CPU rating = 16934 / 2D = 820 / 3D= 8849 / Mem = 2991 / Disk = 13794] 4.24.17 Single Thread Mark = 2252
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