Desktop Hardware and Upgrade Questions

My PCie serial card (Vantec) and IOGEAR USB-to-serial cable quit working.  Neither SecureCRT or Putty will connect.  Unable to access serial port - connection denied even though COMx assignment matches Device Manager status.  All other USB devices work fine including UPS, Label Printer, Fax Modem (StarTech).  I tried updating drivers to latest, I even went into the registry and cleared the Com Name assignment and reconnected the devices one at a time with the same result.  The USB-to-serial cable works great with my Win11 laptop (Lenovo) and with my old HP Win7 laptop, but won't work at all on this tower.  My older TrendNet USB to serial cable quit working with the Z1 Tower as well.   It a nutshell, I have exhausted all avenues to get serial access to my Tower.  I use the serial port to access console ports on network and telecommuications equipment.  The devices work on either PC's.  I even removed the PCIe serial card from the Z1 tower and installed it in an old Win7 PC, and it worked fine.  So did the IOGEAR USB serial adapter.