manual restart when computer goes to sleep

[teachertwinmom]

When my computer goes to sleep I often have to manually turn if off and on again because the mouse won't work.  Sometimes the mouse or keyboard will work, but not always.  I have gone to settings and made sure the mouse and keyboard both are set to wake the computer up.  

[WAWood]

@teachertwinmom 

Win10 has enabled a new hibernation process known as Fast Startup -- which is enabled BY DEFAULT. This is different from Fast Boot, which is a BIOS/UEFI option.

Fast Startup is supposed to dramatically speed up the booting process, but in some PCs, it actually slows it down or causes it to hang. It's also a new form of hibernation known as hybrid sleep -- and this causes battery drain to maintain the state of the PC while turned off.

Disabling Fast Startup might fix booting and shutdown problems.

There are two ways to disable FastStartup in Win10: (1) through the Control Panel, and (2) through an elevated command prompt.

Control Panel - Open Control Panel --> Power Options.
Select "Choose what the power buttons do"
Select "Change settings that are currently unavailable"
At the bottom of the Window, under Shutdown settings, uncheck the box regarding fast startup

Elevated command prompt - run the following command:
REG ADD "HKLM\SYSTEM\CurrentControlSet\Control\Session Manager\Power" /V HiberbootEnabled /T REG_dWORD /D 0 /F

In both cases, reboot Windows.

NOW, FastStartup is disabled.

See if that helps.