You're holding down the CTRL key

[Kishor6363]

HP Notebook - 15s-dr0001tu

1> You're holding down the CTRL key. Do you Want to start Excel in safe mode?

2> Click on My PC - Drive show up -- but not able to click further

3> On Desk Top multiple files and Shortcuts get auto selected in one click

[praveen196]

@Kishor6363 Welcome to HP Community!

Try updating the computer, this will install the latest updates -

Step 1 Windows Updates -

1) In the search box, type, and open Windows Updates.

2) Check for updates.

3) If the updates are available, click on install and restart the computer.

Step 2 Install updates using HP Support Assistant

1. In the search box, type, and open HP Support Assistant. 
2. Check for updates. 
3. If the updates are available, click on install and restart the computer.  

Note: If you do not have HP Support Assistant installed, Click here to download the same.

Please run the SFC scan. you can refer to this Link: https://support.microsoft.com/en-in/help/4026529/windows-10-using-system-file-checker

Keep us posted,

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Give us a virtual high-five by clicking the 'Thumbs Up' icon below, followed by clicking on the "Accept as solution" on this post, 

Have a great day!